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This involves reprogramming of stem and progenitor cell populations to improve cell survival, differentiation, recruitment potency, and functions of vessels

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Hematoxylin and eosin (H&E) and Safranin O staining demonstrated extensive destruction of trabecular architecture and marrow necrosis in femoral head tissues from GC-induced ONFH patients, markedly exceeding the pathological changes observed in non-ONFH controls (Fig